Domerin (Domperidone Maleate)

Use the lowest effective dose for the shortest possible duration, as directed by a qualified healthcare professional. For adults, current safety recommendations in many jurisdictions limit oral dosing to 10 mg up to three times daily, with a maximum of 30 mg per day and treatment usually not exceeding one week. Follow the locally approved product leaflet and prescription.

Do not use in patients with known hypersensitivity to Domperidone, gastrointestinal bleeding, mechanical obstruction or perforation, prolactinoma, significant cardiac conduction abnormalities, or certain underlying heart conditions. Concomitant use with potent CYP3A4 inhibitors or medicines that prolong the QT interval is contraindicated in relevant product guidance.

Domperidone has been associated with QT prolongation, serious cardiac arrhythmias, and sudden cardiac death. Risk may be higher in people over 60 years of age, those taking more than 30 mg daily, or those using interacting medicines. Use particular caution in patients with heart disease, electrolyte disturbances, or liver impairment. Seek urgent medical attention for palpitations, fainting, or other symptoms suggestive of a heart rhythm problem.

Possible side effects include dry mouth, headache, abdominal cramps, and diarrhea. Increased prolactin levels may cause breast tenderness or milk discharge. Serious but uncommon risks include abnormal heart rhythms and severe allergic reactions.

Important interactions include QT-prolonging medicines, potent CYP3A4 inhibitors such as certain macrolide antibiotics and azole antifungals, and other medicines that may increase the risk of cardiac arrhythmias. Inform the healthcare professional about all medicines and supplements being taken.

Pregnancy: Use only if specifically advised by a qualified healthcare professional. Breastfeeding: Consult a healthcare professional before use; domperidone passes into breast milk and may pose risks. Children: Use only when specifically prescribed and appropriate for the patient's age and weight. Older adults and patients with heart, liver, or kidney conditions require careful assessment.

100 Tablets